Signal Transduction Reagents and Kits
Cell Signaling Technology SignalSlide Phospho-Met (Tyr1234/1235) IHC Controls 1 Pack
SignalSlide Phospho-Met (Tyr1234/1235) IHC Controls 1 Pack
Revvity Health Sciences Inc HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
Enzo Life Sciences PD-98059, (5mg), CAS Number: 167869-21-8
MEK inhibitor. PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest. Formula: C16N13NO3. MW: 267.3. CAS Number: 167869-21-8. Purity: ≥95% (HPLC). Appearance: Pale yellow solid. Solubility: Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml). Long Term Storage: -20°C
Enzo Life Sciences Z-prolyl-prolinal (25mg). CAS: 86925-97-5
A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides. Alternative name: Z-PP-CHO. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Medchemexpress LLC Veratridine | 71-62-5 | 10 MG
Veratridine is a plant neurotoxin and a voltage-gated sodium channel (VGSCs) agonist. It inhibits the peak current of Nav1.7 with an IC50 of 18.39 μM. It regulates sodium ion channels by activating them, preventing channel inactivation, and increasing sodium ion flow. This product is for research use only.
- Plant neurotoxin
- Voltage-gated sodium channels (VGSCs) agonist
- Inhibits peak current of Nav1.7
- Regulates sodium ion channels by activation
- Prevents channel inactivation
- Increases sodium ion flow
Medchemexpress LLC Tulobuterol (C-78 free base) | 41570-61-0 | 99.7% | 50 MG
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
- Decreases RV14 RNA levels at 1 day and 3 days after infection in human tracheal epithelial cells.
- Significantly lowers sICAM-1 concentrations in cell supernatants.
- Reduces the number and fluorescence intensity of acidic endosomes.
- Decreases RV14 infection-induced secretion of IL-1β, IL-6, and IL-8.
- Produces a small but significant reduction in p50, p65, and c-Rel of NF-κB induced by RV14 infection.
- Maintains diaphragm muscle contractility for over 24 hours in a mouse model of sepsis.
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Enzo Life Sciences Lysophosphatidic acid, (5mg), CAS Number: 325465-93-8
LPA receptor ligand. Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative Name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Formula: C21H40O7P . Na. MW: 458.5. CAS Number: 325465-93-8. Purity: ≥98% (TLC). Appearance: Waxy solid. Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Use/Stability: Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. Long Term Storage: -20°C
Echelon Biosciences Research Labs EICOSANOYL LPA 1 mg
Arachidoyl LPA, 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA), a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Enzo Life Sciences (±)-Verapamil . hydrochloride (5g). CAS: 152-11-4
Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines. Alternative name: 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl. Purity: ≥99% (HPLC). Appearance: White crystalline powder. Solubility: Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml). Long Term Storage: Ambient.
Carnabio Usa Inc CK1G1(CSNK1G1)/10UG/FULL-LENGT
CK11(CSNK1G1), Full-length, Wild type, Amino Acid 1-422, NP_071331.2, Expressed in Insect (sf21); 10microg