Signal Transduction Reagents and Kits
BPS Bioscience Inc SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties
SBE Reporter HEK293 Cell Line, 2 vials of frozen cells, 2 x 10^6 cells in 1 ml of cell freezing medium, ~1.5 x 10^6 cells in 1 ml of 10% DMSO, >1 x 10^6 cells in 1 ml of freezing medium, adherent growth properties
Enzo Life Sciences PROTEOSTAT Thioredoxin-1 assay kit (2x96wells)
Applications: Fluorescent detection. Contents: PROTEOSTAT PDI detection reagent: 20 μL. Thioredoxin-1 (human) (recombinant): 2 vials x 80 μL. Insulin: 2 vials x 1.8 μmol. Aurothiomalate (inhibitor): 2 vials x 25 nmol. PBE buffer: 25 mL. Stop reagent: 1 mL. DTT: 2 vials x 1.3 mL. Deionized water: 5 mL
Akoya Biosciences TSA(TM) FLUORESCEIN SYSTEM (50
TSA, Fluorescein System, for 50-150 Slides. These systems are designed for direct fluorescence detection in ISH or IHC procedures.
Enzo Life Sciences SAG, (1mg), CAS Number: 364590-63-6
Smoothened ligand. A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Formula: C28H28ClN3OS. MW: 490.1. CAS Number: 364590-63-6. Purity: ≥95% (HR-MS, 1H-NMR, 13C-NMR). Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility). Use/Stability: Stable for at least 6 months when stored at -20°C. Long Term Storage: -20°C
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 1 mg
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable
Enzo Life Sciences SB-202190 (1mg). CAS: 152121-30-7
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis. Alternative name: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Purity: ≥98% (TLC). Solubility: Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. Long Term Storage: -20°C.
Enzo Life Sciences MMP-Inhibitor profiling kit, colorimetric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a chromogenic substrate1,2 detected at 412nm. Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Colorimetric detection, HTS Activity assay.
Enzo Life Sciences Matrix Metalloproteinase-14 (MMP-14) colorimetric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-14 Colorimetric Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well plate format. Also included are active enzyme, a prototypic control inhibitor (NNGH), and a detailed instruction booklet. Alternative name: Membrane type matrix metalloproteinase 1, MT-1 MMP. Applications: Colorimetric detection, HTS Activity assay.
CPC Scientific Ac-Tyr-Val-Lys-Asp-CHO 1MG
Affinity ligand for interleukin-1b converting enzyme. Slow binding caspase-1 (ICE) inhibitor with low selectivity.SEQUENCE: Ac-Tyr-Val-Lys-Asp-CHOONE-LETTER SEQUENCE: Ac-YVKD-CHOMOLECULAR FORMULA: C26H39N5O8MOLECULAR WEIGHT: 549.6STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [147821-01-1]SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:T.L. Graybill et al., Int. J. Peptide Protein Res., 44, 173 (1994)N.A. Thornbery et al., Nature, 356, 768 (1992)SKU(s): CASP-015A
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B
Creative Biomart Human F7/Coagulation factor VII human
The product is human serine protease type enzyme that is involved in the extrinsic coagulation cascade which results in blood clotting.
CPC Scientific Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt) 5MG
Nonapeptide capable of inhibiting the conversion of angiotensin I to angiotensin II, in vitro and in vivo. Bradykinin Potentiator.SEQUENCE: Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: Glp-WPRPQIPPMOLECULAR FORMULA: C53H76N14O12MOLECULAR WEIGHT: 1101.3STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [35115-60-7]SYNONYMS: RESEARCH AREA: CardiovascularREFERENCES:M.A. Ondetti et al., Biochemistry, 10, 4033 (1971)H.S. Cheung and D.W. Cushman, Biochim. Biophys. Acta, 293, 451 (1973)L.C. Martin et al., Biochem. J., 184, 713 (1979)D.I. Marlborough et al., Arch. Biochem. Biophys., 210, 43 (1981)SKU(s): ACEI-001A, ACEI-001B, ACEI-001C
Sigma Aldrich Fine Chemicals Biosciences Mitoxantrone dihydrochloride 97 (HPLC), 70476-82-3, MFCD00242943
Mitoxantrone dihydrochloride 97 (HPLC)
Enzo Life Sciences MMP-1 Colorimetric Assay Buffer (20ml)
Formulation: Liquid. In 50 mM HEPES, 10 mM calcium chloride, 0.05% Brij-35, 1 mM DTNB, pH 7.5. Long Term Storage: -20°C.